Antithrombin-III for New Coronavirus Infection (COVID-19) Under Conditions of Extracorporeal Membrane Oxygenation (Clinical Observation

COVID-19 is a disease that, in addition to respiratory failure, leads to thrombosis and bleeding due to coagulation disorders. Extracorporeal membrane oxygenation (ECMO), required in cases of a deterioration of gas exchange function of the lungs, contributes to changes in blood coagulation indicators, which leads to an increased risk of hemorrhagic complications and thrombosis. In the article, a clinical case of a severe course of COVID-19 is reported, which required ECMO. During the treatment, antithrombin-III was used, which allowed avoiding life-threatening complications and successfully completing the procedure. © 2021 Sklifosovsky Research Institute for Emergency Medicine. All rights reserved.

Thermovaccination: Thermoheliox as an Immune Response Stimulant. Kinetics of Antibodies and C-Reactive Protein Synthesis in Coronaviral Infection.

The high efficiency of using thermoheliox (inhalation with a high-temperature mixture of helium and oxygen) in the treatment of patients affected by COVID-19 was shown. The dynamics of accumulation of IgG, IgM, and C-reactive protein (CRP) in patients with coronavirus infection in the "working" and control groups was studied experimentally. It was shown that thermoheliox intensifies the synthesis of IgG, IgM, and CRP antibodies, while eliminating the induction period on the kinetic curves of the synthesis of specific antibodies in the IgG form and transfers the synthesis of CRP to a fast phase. The results of experiments confirm the previously obtained data based on the analysis of the kinetic model of the development of coronaviral infection in the human body.

Effect of thermal helium-oxygen mixture on viral load in COVID-19

In this paper, we will discuss the use of t-Не/О2 in the treatment of patients with the viral disease COVID-19. The aim of the study is to evaluate the effect of thermal helium-oxygen therapy on viral load, inflammatory markers, and antibody synthesis. Methods. A single-center, randomized, prospective study included 60 patients with COVID-19. Patients were divided into two groups: 1 (n = 30;17 male, 13 female) - t-Не/О2 therapy was included in the standard COVID-19 treatment Protocol;2 (n = 30;16 male, 14 female) - standard therapy in accordance with the clinical recommendations of Healthcare Ministry of Russia for patients with COVID-19. Of the 60 patients included in the study, 28 (46.7%) were medical professionals. The median age of patients in the study was 56.7 (45 - 61) years old. In the group 1 - 58 (45 - 59.5) years old, in the group 2 - 55 (46 - 66) years old. All patients had a positive test of SARS-CoV-2 coronavirus RNA, CT signs of “ground-glass opacity” type lung damage, and areas of air space consolidation. Patients were comparable by gender, age, body mass index (BMI), area of lesion of the pulmonary parenchyma, laboratory data. Results. As a result of the use of t-Не/О2, the elimination of the SARS-CoV-2 virus occurred within 48 - 72 hours from the start of inhalation and was confirmed by PCR test. The following changes were found in all patients: synthesis of IgM and IgG antibodies, increase in lymphocytes level, decrease of C-reactive protein, restoration of alanine aminotransferase and aspartate aminotransferase levels, D-dimer, and ferritin. These signs became more pronounced in the 1st group within 72 - 168 hours, compared with the 2nd group, where these results were achieved on the 10th day of therapy. Conclusion. Тhe inclusion of thermal inhalation a gas mixture of helium and oxygen (t-Не/О2) in the standard therapy of patients carrying infectious disease caused by SARS-CоV-2 with CT signs of COVID-19 pneumonia (СT1, CT2 grades) reduces the viral load by stimulating antibody synthesis, as the type of immunoglobulin G, and immunoglobulin M causing the effect of “termovaccination”;increases the effectiveness of treatment, reducing the markers of inflammation. © 2020 Medical Education. All rights reserved.

Epidemiology, clinical picture, diagnostics, assessment of the severity of the disease COVID-19

The analysis of the epidemic process associated with COVID-19 is carried out, possible scenarios of the development of events are presented. The most common anamnestic data, symptoms of infection, clinical picture and possible complications are described in detail. The features of the COVID-19 course in risk groups and the algorithms of administrative and medical actions that should underlie the provision of medical care to patients with cardiovascular, oncological, rheumatological diseases, pregnant women, etc. The section of diagnostics and examination features is of particular importance, since it includes not only the definition of the causative agent of the disease, but also the main indicators that determine the severity of the clinical picture, prognosis, the nature and extent of medical care. Considerable experience is presented in the clinical practice of computed tomography of the lungs, the method, the primary and early method for identifying not only lung lesions, but also the underlying disease - COVID-19. Information is presented from literary sources based on the experience of overcoming this formidable disease and its consequences by our colleagues, as well as the experience of domestic clinicians and scientists. © 2020 Baltic Medical Educational Center.